Welcome to the Orvedahl lab!

We utilize a combination of hypothesis-driven and discovery-based approaches to understand factors that regulate host immune responses to infectious and sterile triggers of severe inflammation.

These posters are meant to show that racial justice and support for marginalized communities cannot be separated from the practice of science. We must actively work to recognize the obstacles that scientists (and potential scientists) from marginalized communities face, and dismantle structures of power that prevent them from succeeding. We must also consider the effects of our research and research choices on marginalized communities. Please see SammyKatta for more! Modified with images from BioRender.com

We focus on the cytoplasmic recycling pathway of autophagy, which we found protected macrophages against cytokine-induced cell death and mice against fatal cytokine storm syndrome. However, the relative protective or pathogenic role of autophagy in macrophage survival remains unclear in different contexts. Preliminary findings point towards a critical intersection of these processes with immunometabolism. We are leveraging this experience and developing novel tools to understand the commonalities and peculiarities of cytokine storm syndromes triggered by various etiologies including SARS-CoV-2. The ultimate goal is to develop host-directed therapies for infectious and inflammatory disorders.

Lab research
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Links and news

Faculty Feature Anthony Orvedahl (Links to an external site)

Faculty Feature Anthony Orvedahl
Anthony Orvedahl, MD, PhD, was born in Denver, CO. He is the product of a professionally eclectic family: his father worked in the aerospace industry; mother was a homemaker and administrative assistant; older brother an accomplished comedian; and younger brother a woodworker. His paternal grandfather designed one of the earliest computers at the Los Alamos […]