Featured publications
Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes
September 2, 2022
Wang YT, Sansone A, Smirnov A, Stallings CL, Orvedahl A. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes. Autophagy. 2022 Sep 2:1-14. doi: 10.1080/15548627.2022.2116675. Epub ahead of print. PMID: 36056542.
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages
January 5, 2021
Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. PMID: 33372156; PMCID: PMC7817147.
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes
December 1, 2020
Cabler SS, French AR, Orvedahl A. A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes. Trends Mol Med. 2020 Dec;26(12):1078-1085. doi: 10.1016/j.molmed.2020.09.012. Epub 2020 Sep 30. PMID: 33051104; PMCID: PMC7524648.
Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes
February 1, 2020
Wang YT, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL, Virgin HW. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020 Feb;5(2):272-281. doi: 10.1038/s41564-019-0633-0. Epub 2020 Jan 20. Erratum in: Nat Microbiol. 2021 Jul;6(7):972. PMID: 31959973; PMCID: PMC7147835.
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock
August 13, 2019
Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. doi: 10.1073/pnas.1822157116. Epub 2019 Jul 25. PMID: 31346084; PMCID: PMC6697821.
Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ
July 1, 2019
Ingle H, Lee S, Ai T, Orvedahl A, Rodgers R, Zhao G, Sullender M, Peterson ST, Locke M, Liu TC, Yokoyama CC, Sharp B, Schultz-Cherry S, Miner JJ, Baldridge MT. Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Nat Microbiol. 2019 Jul;4(7):1120-1128. doi: 10.1038/s41564-019-0416-7. Epub 2019 Apr 1. PMID: 30936486; PMCID: PMC6588490.
Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine
October 11, 2017
Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW. Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. Cell Host Microbe. 2017 Oct 11;22(4):449-459.e4. doi: 10.1016/j.chom.2017.08.021. Epub 2017 Sep 28. PMID: 28966054; PMCID: PMC5679710.
Clinical Characterization of Children Presenting to the Hospital with Enterovirus D68 Infection During the 2014 Outbreak in St. Louis
May 1, 2016
Orvedahl A, Padhye A, Barton K, O’Bryan K, Baty J, Gruchala N, Niesen A, Margoni A, Srinivasan M. Clinical Characterization of Children Presenting to the Hospital with Enterovirus D68 Infection During the 2014 Outbreak in St. Louis. Pediatr Infect Dis J. 2016 May;35(5):481-7. doi: 10.1097/INF.0000000000001060. PMID: 26771663; PMCID: PMC5237429.
Image-based genome-wide siRNA screen identifies selective autophagy factors
December 1, 2011
Orvedahl A, Sumpter R Jr, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 2011 Dec 1;480(7375):113-7. doi: 10.1038/nature10546. PMID: 22020285; PMCID: PMC3229641.
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
March 15, 2007
Orvedahl A, Alexander D, Tallóczy Z, Sun Q, Wei Y, Zhang W, Burns D, Leib DA, Levine B. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe. 2007 Mar 15;1(1):23-35. doi: 10.1016/j.chom.2006.12.001. PMID: 18005679.
Recent publications
- Autophagy gene-dependent intracellular immunity triggered by interferon-γMcAllaster, M. R., Bhushan, J., Balce, D. R., Orvedahl, A., Park, A., Hwang, S., Sullender, M. E., Sibley, L. D. & Virgin, H. W., Dec 2023, In: mBio. 14, 6Research output: Contribution to journal › Article › peer-review
- Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromesWang, Y. T., Sansone, A., Smirnov, A., Stallings, C. L. & Orvedahl, A., 2023, In: Autophagy. 19, 4, p. 1114-1127 14 p.Research output: Contribution to journal › Article › peer-review
- Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpinsLuke, C. J., Markovina, S., Good, M., Wight, I. E., Thomas, B. J., Linneman, J. M., Lanik, W. E., Koroleva, O., Coffman, M. R., Miedel, M. T., Gong, Q., Andress, A., Campos Guerrero, M., Wang, S., Chen, L. Y., Beatty, W. L., Hausmann, K. N., White, F. V., Fitzpatrick, J. A. J. & Orvedahl, A. & 2 others, Pak, S. C. & Silverman, G. A., Dec 2022, In: Communications Biology. 5, 1, 47.Research output: Contribution to journal › Article › peer-review
- Lrp1 is a host entry factor for Rift Valley fever virusGanaie, S. S., Schwarz, M. M., McMillen, C. M., Price, D. A., Feng, A. X., Albe, J. R., Wang, W., Miersch, S., Orvedahl, A., Cole, A. R., Sentmanat, M. F., Mishra, N., Boyles, D. A., Koenig, Z. T., Kujawa, M. R., Demers, M. A., Hoehl, R. M., Moyle, A. B., Wagner, N. D. & Stubbs, S. H. & 14 others, Cardarelli, L., Teyra, J., McElroy, A., Gross, M. L., Whelan, S. P. J., Doench, J., Cui, X., Brett, T. J., Sidhu, S. S., Virgin, H. W., Egawa, T., Leung, D. […]
- Author Correction: Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes (Nature Microbiology, (2020), 5, 2, (272-281), 10.1038/s41564-019-0633-0)Wang, Y. T., Zaitsev, K., Lu, Q., Li, S., Schaiff, W. T., Kim, K. W., Droit, L., Wilen, C. B., Desai, C., Balce, D. R., Orchard, R. C., Orvedahl, A., Park, S., Kreamalmeyer, D., Handley, S. A., Pfeifer, J. D., Baldridge, M. T., Artyomov, M. N., Stallings, C. L. & Virgin, H. W., Jul 2021, In: Nature microbiology. 6, 7, p. 972 1 p.Research output: Contribution to journal › Comment/debate